November 06, 2026 | Injectables, Plastic Surgery News
“They are afraid of looking frozen or wrong for four months.”
That is what I hear from people who have never tried toxin. A new one, Boey, was approved in Europe on July 17, 2026. It works within hours and is gone in two to three weeks. Dazed called it “try before you buy” Botox.
It is not approved in the United States, so it is not in my office.
What Boey Is
“Boey (trenibotulinumtoxinE) is a serotype E toxin, which is a different family from Botox and the other type A products.”
A neuromodulator relaxes a muscle by blocking the nerve signal where nerve meets muscle. With type A, the effect lasts months.
| Type A (Botox, Dysport, Jeuveau) | Type E (Boey) | |
|---|---|---|
| Duration | Three to four months | About two to three weeks |
| Onset | Days | As early as 8 hours, in the trials |
| Approved in the US | Yes | No |
| Approved in Europe | Yes | Yes, July 17, 2026, frown lines in adults |
Who It Is For, and Who It Is Not
The first-timer. I get mine on a schedule: “I myself get botulinum toxin in the forehead, crow’s feet, and glabella lines every three to four months, just to maintain the wrinkle free appearance with a dose that still lets me express my face without looking abnormal.”
“I think Botox is something you just kind of have to keep doing, because it gives us the best result for this area.”
“It really is a maintenance therapy.”
How Long Type A Lasts
Does exercise make it wear off faster?
“The short answer is yes, but the difference is not that great. There are no scientific studies on this question. What we do have is a lot of small reports and patient anecdotes.”
“I see very active patients, runners and high-intensity athletes, tend to come back for Botox in about two and a half to three months. At the same time, I see my more sedentary, less active patients at four months.”
Short Does Not Mean Safe
In the Boey trials, eyelid ptosis and brow ptosis (a drooping lid or brow) were among the most common side effects. Two weeks of a droopy lid is still a droopy lid.
“We see a good number of patients where the botulinum toxin is incorrectly applied resulting in eyelid droopiness, brow droopiness, and uneven smiles.”
What decides the result?
“Dose, dilution, injection placement, and product choice matter more than whether you are active or inactive. These are all customized depending on each patient’s consultation. For example, patients with very strong frontalis muscles, glabellar muscles, or masseters will require a higher dose than others.”
And after the injection?
“I do ask patients not to exercise for twenty-four hours after a botulinum toxin injection, but this is not because it is going to wear off sooner. It is because I want the solution to stay exactly where I injected it, and strenuous exercise immediately after an injection could increase the risk of the product migrating, complications, and swelling.”
If Someone Offers It to You Here
Then it did not come through an approved channel. That is the problem in my post on the CDC’s Colorado report.
“The danger with counterfeit products is that we only find out because they go to the ED because of severe life threatening complications. Some counterfeit products result in no result at all because they do not contain the botulinum toxin.”
“We buy directly from the manufacturers, Galderma, Allergan, and Evolus. The toxin is shipped to us directly from them in temperature controlled containers. The vials are stored in a medical temperature controlled refrigerator that is monitored 24 hours a day for temperature variations.”
“Patients can see the vial at any time.”
What a First-Timer Can Do Today
A light first dose, and a check at two weeks. The med spa version of this post is on the Southwest Plastic Surgery site, and my surgeon’s read is on drworldwide.com. More on Botox and what Botox does beyond wrinkles.
Why Choose Dr. Agullo
I am certified by the American Board of Plastic Surgery and the American Board of Surgery, trained in plastic surgery at the Mayo Clinic, and teach as Clinical Associate Professor of Plastic Surgery at Texas Tech University Health Sciences Center Paul L. Foster School of Medicine.
Ready to Talk?
Call (915) 590-7900, text 1-866-814-0038, or book online at agulloplasticsurgery.com. #StayBeautiful
Find me at @RealDrWorldWide on Instagram, TikTok, and Snapchat, @Agullo on X, or @AgulloPlasticSurgery on Facebook.
